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Quinine HCl Dihydrate

CAS No. 6119-47-7

Quinine HCl Dihydrate( —— )

Catalog No. M18893 CAS No. 6119-47-7

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Quinine HCl Dihydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
  • Description
    Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
  • In Vitro
    Cell Proliferation Assay Cell Line:Human hepatocarcinoma cell line(HepG2) Concentration:150 μM Incubation Time:30 min Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
  • In Vivo
    Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g) Dosage:Swiss albino mice 7-8-weeks (weighing 24 g) Administration:Oral gavage; every week; 16 weeks Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    SGLT
  • Recptor
    Potassium channel
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    6119-47-7
  • Formula Weight
    396.91
  • Molecular Formula
    C20H24N2O2·HCl·2H2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 251.95 mM H2O : 20 mg/mL50.39 mM;
  • SMILES
    O.O.Cl.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)C1=CC=NC2=C1C=C(OC)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Srinivas M, et al. Proc Natl Acad Sci U S A,2001, 98(19), 10942-10947.
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